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Testing Status of Coumarin 10104-F

 

CASRN: 91-64-5

Formula: C9-H6-O2

Synonyms/Common Names

  • 2H-1-Benzopyran-2-one

Known Uses

Odor enhancing agent in perfumes. Pharmaceutic aid (flavor). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C07103A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 5 days (Gavage)  (C10104)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 3.125, 6.25, 12.5, 25, 50, 100, 200, or 400 mg/kg; N=4.
  • 13-Week (Gavage)  (C07103A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 400, M: 0, 30, 150 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C07103B)  Completed 
    • TR-422 (NIH Number: 93-3153)  (Peer Review Approval 06/23/1992A )
      Toxicology and Carcinogenesis Studies of Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 25, 50, 100; M: 0, 50, 100, 200 MG/KG/60 & 70 PER GROUP RESPECTIVELY.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (020274)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Drosophila  (496820)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (737193)  Completed 
    • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (820766)  Completed 
    • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A80637)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (879172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T10104)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley