National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10106-n

Testing Status of 2,4-Diaminophenol dihydrochloride - 10106-N

 

CASRN: 137-09-7

Related: 2,4-DIAMINOPHENOL HYDROCHLORIDE 29849-01-2

Formula: C6-H8-N2-O.2Cl-H

Synonyms/Common Names

  • Dianol

Known Uses

Photographic developer. Dyeing furs and hair. Analytical reagent.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C60026)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C60026)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60026)  Report Complete 
    • TR-401 (NIH Number: 92-2856)  (Peer Review Approval 03/11/1991A )
      NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CASRN 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,12.5,25, M: 0,19,38 MG/KG/60 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (729737)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (431842)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Mouse Lymphoma  (299952)  Completed 
    • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
    • Mice
    •  Positive 
  • Salmonella  (539410)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.