National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10108-w

Testing Status of cis-Dichlorodiamine platinum - 10108-W

 

CASRN: 15663-27-1

Formula: Cl2-H6-N2-Pt

Synonyms/Common Names

  • Cisplatin
  • cis-Platinum
  • Diamminedichloroplatinum
  • Platinol
  • Platinum diamminodichloride

Known Uses

Antineoplastic agent for treatment of bladder, ovarian, and testicular cancer.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (593235)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (059070)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Salmonella  (839608)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • single exposure Dominant Lethal (Intraperitoneal Injection)  (TER94004)  Completed 
    • Male Rats: Sprague Dawley
    • Dose: 0, 6, 8, 10, 12 MG/KG IN DRF STUDY; 0 & 8 MG/KG DL STUDY.
  • Dominant Lethal (Female) (Gavage)  (DLF061)  Completed 
    • Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Female) (Dosed-Feed)  (DLF062)  Completed 
    • Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
    • Female Mice: SEC X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Male) (Dosed-Feed)  (DLM060)  Completed 
    • Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
    • Male Mice: C3H X 101
    • Mice Male Negative 
  • Continuous Breeding (Legacy) (Gavage)  (RACB94020)  Completed 
    • Male Rats: CD-1
  • Total Reproductive Capacity (Gavage)  (TRC98027)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice: B6C3F1/N
    • Mice Female Positive 
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