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Testing Status of Vinylidene Chloride 10109-A

 

CASRN: 75-35-4

Formula: C2-H2-Cl2

Synonyms/Common Names

  • 1,1-Dichloroethene (9CI)
  • Dichloroethylene,1,1

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C20303)  Completed 
    •   (Peer Review Approval 10/29/2013A ) Citation: Hayes SA, Pandiri AR, Ton TV, Hong HH, Clayton NP, Shockley KR, Peddada SD, Gerrish K, Wyde M, Sills RC, Hoenerhoff MJ. Renal cell carcinomas in vinylidene chloride-exposed male B6C3F1 mice are characterized by oxidative stress and TP53 pathway dysregulation. Toxicol Pathol. 2016 Jan;44(1):71-87
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 25, 50, 100, 200, or 400 ppm; 5/sex/species/dose.
  • 14-Day (Gavage)  (C54262)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Inhalation)  (C20303)  Completed 
    • Citation: Hayes SA, Pandiri AR, Ton TV, Hong HH, Clayton NP, Shockley KR, Peddada SD, Gerrish K, Wyde M, Sills RC, Hoenerhoff MJ. Renal cell carcinomas in vinylidene chloride-exposed male B6C3F1 mice are characterized by oxidative stress and TP53 pathway dysregulation. Toxicol Pathol. 2016 Jan;44(1):71-87
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&FM: 0, 6.25, 12.5, 25, 50, or 100 ppm; MM: 0, 6.25, 12.5, 25, or 50 ppm; R: 20/sex/dose; M: 10/sex/dose.
  • 13-Week (Gavage)  (C54262)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 5, 250 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20303)  Completed 
    •   (Peer Review Approval 10/29/2013A ) Citation: Hayes SA, Pandiri AR, Ton TV, Hong HH, Clayton NP, Shockley KR, Peddada SD, Gerrish K, Wyde M, Sills RC, Hoenerhoff MJ. Renal cell carcinomas in vinylidene chloride-exposed male B6C3F1 mice are characterized by oxidative stress and TP53 pathway dysregulation. Toxicol Pathol. 2016 Jan;44(1):71-87
    • TR-582 (NIH Number: 15-5924)  (Peer Review Approval 10/29/2013A )
      Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 25, 50, or 100 ppm; M: 0, 6.25, 12.5, or 25 ppm; 50/sex/species/dose.
  • 2-Year (Gavage)  (C54262)  Completed 
    • TR-228 (NIH Number: 82-1784)  (Peer Review Approval 02/18/1981A )
      Carcinogenesis Bioassay of Vinylidene Chloride (CASRN 75-35-4) in F344 Rats and B6C3F1 Mice (Gavage Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 1, 5, M: 0, 2, 10 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Drosophila  (883501)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (953885)  Completed 
    • Citation: McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
    • Mice
    •  Positive 
  • Micronucleus  (A71539)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (121030)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative