National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10110-x

Testing Status of cis & trans 1,2-Dichloroethylene - 10110-X

 

CASRN: 540-59-0

Formula: C2-H2-Cl2

Synonyms/Common Names

  • Ethene, 1,2-dichloro-

Known Uses

Solvent. Fermentation retarder. Organic synthesis. Perfumes. Lacquers. Dye extraction.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Microencapsulation in Feed)  (C56031)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3175, 6250, 12500, 25000, OR 50000 (5/SEX/SPECIES/GROUP).

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (820480)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (976471)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 4 to 15 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91022)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, .05, .25, .5, 1.0, OR 1.5%.
  • Teratology Pilot Studies (Dosed-Feed)  (TRP91031)  Completed 
    • Mice: Swiss
    • Dose: 0, 1.5, 5, 10%.
  • 6 to 15 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91032)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, .2, 1, 2, 3, OR 4%.
  • 6 to 15 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91033)  Completed 
    • Rats: Sprague Dawley
    • Dose: 0, 4, 7.5, 10%.
  • Teratology Pilot Studies (Gavage)  (TRP92065)  Completed 
    • Rats
    • Dose: 0, 200, 500, 1000, 2000, 3000 MG/KG.
  • Teratology Pilot Studies (Gavage)  (TRP92066)  Completed 
    • Rabbit: New Zealand White
    • Dose: 0, 200, 500, 1000, 2000 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.