National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10112-f

Testing Status of Diethyl phthalate - 10112-F

 

CASRN: 84-66-2

Formula: C12-H14-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, diethyl ester
  • DEP

Known Uses

In manufacture of celluloid, cosmetics, varnishes, and dopes. Plasticizer for cellulose ester plastics. Insecticide sprays. Used as phthalate plasticizers, in an extensive array of products. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 4 weeks (Topical Application)  (C60048B)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C60048B)  Report Complete 
    • TR-429 (NIH Number: 95-3356)  (Peer Review Approval 11/17/1993A )
      Toxicology and Carcinogenesis Studies of Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CASRN 131-11-3) in Male Swiss (CD-1®) Mice
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0,100,300 M: 0,7.5,15,30 UL/100 UL SOLUTION /50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0044)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (306322)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (913646)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (364986)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (576172)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB83092)  Completed 
    • Citation: Final Report - Diethyl Phthalate: Reproduction and Fertility Assessment In CD-1 Mice When Administered in the Feed
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,.25,1.25,2.5% IN FEED; N/A; 0,2.5%.
  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0033A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 4500 MG/KG BODY WEIGHT.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER88065)  Completed 
    • Citation: Developmental Toxicity Evaluation of Diethyl Phthalate Administered to CD Rats on Gestational Days 6 through 15
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0.25, 2.5, 5.0 %.
  • Utero-Lactational (Gavage)  (R10112)  Completed 
    • Rats: Harlan Sprague-Dawley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.