National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10113-j

Testing Status of 3,4-Dihydrocoumarin - 10113-J

 

CASRN: 119-84-6

Formula: C9-H8-O2

Synonyms/Common Names

  • 3,4-Dihydro-2H-1-benzopyran-2-one

Known Uses

Fragrance in cosmetics and detergents. Flavoring agent in foods and beverages. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55890A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55890A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 75, 1200, M: 0, 100, 1600 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55890B)  Report Complete 
    • TR-423 (NIH Number: 93-3154)  (Peer Review Approval 06/23/1992A )
      Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 150, 300, 600, M: 0, 200, 400, 800 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (733791)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A43806)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (911172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.