National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10114-n

Testing Status of Dimethoxane - 10114-N

 

CASRN: 828-00-2

Formula: C8-H14-O4

Synonyms/Common Names

  • 2,6-Dimethyl-1,3-dioxan-4-ol acetate

Known Uses

Preservative for cutting oils, resin emulsions, cosmetics, inks, and water-based paints. Antimicrobial agent in adhesives and textile chemicals. Gasoline additive.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56213)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56213)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56213)  Report Complete 
    • TR-354 (NIH Number: 89-2809)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Dimethoxane (CASRN 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: MR: 0,62.5,125, FR: 0,125,250, M: 0,250,500 MG/KG/60 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (028235)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (194110)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
  • Salmonella  (742172)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
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