Testing Status of Ethylene glycol monoethyl ether (EGMEE) 10117-A

 

CASRN: 110-80-5

Formula: C4-H10-O2

Synonyms/Common Names

  • Cellosolve
  • EGMEE
  • 2-Ethoxyethanol

Known Uses

Solvent for nitrocellulose, lacquers, dopes, in varnish remover, cleaning solutions, dye baths, increase stability of emulsions (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C54853B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Water)  (C54853B)  Report Complete 
    • TOX-26 (NIH Number: 93-3349)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: CORE STUDY: R: 0, 1250, 2500, 5000, 10000, 20000, M: 0, 2500, 5000, 10000, 20000, 40000 PPM/10 PER GROUP STOP STUDY: R: 0, 5000, 10000, 20000 PPM/30 PER GROUP.
  • 8 weeks (Dosed-Water)  (C54853D)  Report Complete 
    • TOX-26 (NIH Number: 93-3349)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N
    • Dose: MALE RATS ONLY: 0, 2500, 5000 PPM/ 20 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0715)  Completed 
    • Citation: Kennedy CH, Bechtold WE, Chang IY, Henderson RF. Effect of dose on the disposition of 2-ethoxyethanol after inhalation by F344/N rats. Fundam Appl Toxicol. 1993 Nov;21(4):486-91.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination  (S0776)  Completed 
    • Citation: Medinsky MA, Singh G, Bechtold WE, Bond JA, Sabourin PJ, Birnbaum LS, Henderson RF. Disposition of three glycol ethers administered in drinking water to male F344/N rats. Toxicol Appl Pharmacol. 1990 Mar 1;102(3):443-55.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (032435)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (589198)  Completed 
    • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (612734)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (075881)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (914172)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • 5 consecutive days Dominant Lethal (Inhalation)  (T0069D)  Completed 
    • Male Rats: Sprague Dawley
    • Dose: 600 ppm 6 hr/days for 5 consecutive days.
  • 5 consecutive days Dominant Lethal (Topical Application)  (T0069G)  Completed 
    • Male Rats: Sprague Dawley
    • Dose: 0.25, .50 ML 4 TIMES/D FOR 5 CONSEC D.
  • Continuous Breeding (Legacy) (Dosed-Water)  (RACB84050)  Completed 
    • Citation: Final Report - 2-Ethoxyethanol: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Water
    • Male and Female Mice: Swiss
    • Dose: 0, .2, .4, .75, 1.5, 3.0%; 0, .5, 1.0, 2.0%; 0, 2.0%; N/A.
  • Continuous Breeding (Legacy) (Gavage)  (RACB92123)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, 70, 250, 700 MG/KG; N/A; N/A.
  • 5 consecutive days Continuous Breeding (Legacy) (Inhalation)  (T0069C)  Completed 
    • Male Mice: B6C3F1
    • Dose: 600 ppm 6 hr/day for 5 consecutive days.
  • 9 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0069J)  Completed 
    • Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
    • Female Mice: Swiss
    • Dose: 3605 MG/KG BW.
  • Pregestation: 7 hr/day, 5 day/wk for 3 wks. Gestation: 7 hr/day , 1 to 19 GD Conventional Teratology (Inhalation)  (T0069A)  Completed 
    • Citation: Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol
    • Female Rats: Wistar
    • Dose: Pregestation: 150, 650 ppm. Gestation: 200, 765 ppm.
  • 1 to 18 GD Conventional Teratology (Inhalation)  (T0069B)  Completed 
    • Citation: Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol
    • Female Rabbit: New Zealand White
    • Dose: 160 or 615 ppm 7 hr/day for 18 days.
  • 7 to 16 GD Conventional Teratology (Topical Application)  (T0069E)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0.25, 0.50 ml 4 times/day for 10 consecutive days.
  • 7 to 16 GD (vaginal sperm = 1 GD) Conventional Teratology (Topical Application)  (T0069F)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0.25 ML 4 TIMES/D.