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Testing Status of Furan 10119-H

 

CASRN: 110-00-9

Formula: C4-H4-O

Synonyms/Common Names

  • Oxacyclopentadiene

Known Uses

Chemical intermediate. Solvent for resins. In lacquer formation. Organic synthesis. And to prepare copolymers used in machine dishwashing products as alternatives to phosphorus- and nitrogen-containing detergents. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C10119B)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 0.125, 0.25, 0.5, 1, 2, 4, 8, or 16 mg/kg; N=4.
  • 14-Day (Gavage)  (C56202)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56202)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R & FM: 0, 4, 60, MM: 0, 2, 30 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C10119)  Completed 
    • Citation: Tryndyak V, de Conti A, Doerge DR, Olson GR, Beland FA, Pogribny IP. Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study. Arch Toxicol. 2016;1-11
    • Rats: F344 (NCTR)
    • Dose: Male Rats only: 0, 0.02, 0.044, 0.092, 0.2, 0.44, 0.92 and 2.0 mg/kg bw/ day/5 days/wk.
  • 2 years (Gavage)  (C56202)  Completed 
    • TR-402 (NIH Number: 91-2857)  (Peer Review Approval 03/11/1991A )
      Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 2, 4, 8, M: 0, 8, 15 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (K10119)  Completed 
    • Male Rats: F344 (NCTR)
    • Dose: 0, 0.05, 0.1, 0.5, 1.0, 2.0, 5.0, 10.0 mg/kg bw.
  • Absorption Disposition Metabolism Elimination (Gavage)  (K10119H)  Completed 
    • Citation: McDaniel LP, Ding W, Dobrovolsky VN, Shaddock JG Jr, Mittelstaedt RA, Doerge DR, Heflich RH. Genotoxicity of furan in Big Blue rats. Mutat Res. 2012 Feb 18;742(1-2):72-8. doi: 10.1016/j.mrgentox.2011.12.011. Epub 2011 Dec 20.Pubmed Abstract
    • Male Rats: Tg.Lac1/C57BL/6 (Big Blue)
    • Dose: 0, 2, 8, 16, 30 mg/kg bw daily for 8 weeks.
  • Absorption Disposition Metabolism Elimination  (S0756)  Completed 
    • Citation: Burka LT, Washburn KD, Irwin RD. Disposition of [14C] furan in the male F344 rat. J Toxicol Environ Health. 1991 Oct;34(2):245-57.Pubmed Abstract
    • Male Rats: F344/N
  • Toxicokinetic Study (Gavage)  (K10119B)  Completed 
    • Male Rats: F344 (NCTR)
    • Dose: 1 mg/kg bw [one dose only].
  • Toxicokinetic Study (Gavage)  (K10119C)  Completed 
    • Male Rats: F344 (NCTR)
    • Dose: 1 mg/kg bw [one dose only].
  • Toxicokinetic Study (Gavage)  (K10119D)  Completed 
    • Male Rats: F344 (NCTR)
    • Dose: 1 mg/kg bw/day.
  • Toxicokinetic Study (Gavage)  (K10119E)  Completed 
    • Male Rats: F344 (NCTR)
    • Dose: 1 mg/kg bw/day.
  • Toxicokinetic Study (Gavage)  (K10119F)  Completed 
    • Male Rats: F344 (NCTR)
    • Dose: 0, 0.1, 0.5, 1.0, 2.0, 4.0 mg/kg bw/ day.
  • Toxicokinetic Study (Gavage)  (K10119G)  Completed 
    • Male Rats: F344 (NCTR)
    • Dose: 8.0 mg/kg bw/ day (dosed daily for 90 days).

Genetic Toxicology

  • Chromosome Aberrations  (635376)  Completed 
    • Mice
    •  Positive 
  • Comet Assay  (G10119C)  Completed 
    • Rats
  • 3 days Comet Assay (Gavage) Selected (G10119)  
    • Rats: F344 (NCTR)
  • In Vitro Cytogenetics (CA/SCE)  (950997)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (591334)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (048853)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Micronucleus  (G10119B)  Completed 
    • Mice: B6C3F1
    • Female Equivocal 
  • Salmonella  (717172)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (734219)  Completed 
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (635376)  Completed 
    • Mice
    • Sister Chromatid  Negative 

Toxicogenomics

  • 5-day Transcriptome Sequencing (Gavage)  (T10119)  On Test 
    • Rats: Harlan Sprague-Dawley