Testing Status of Furfural 10120-F

 

CASRN: 98-01-1

Formula: C5-H4-O2

Synonyms/Common Names

  • 2-Furancarboxaldehyde (9CI)

Known Uses

Intermediate In plastics preparation, wetting & flavoring agent, preparation of furfural alcohol, insecticide, fungicide, germicide, refining petroleum oils, solvent for cotton, dyes (HSDB 1990). Occurs in essential oils, coffee, rum (food, cosm tox). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56177)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56177)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 11, 180, M: 0, 75, 1200 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56177)  Report Complete 
    • TR-382 (NIH Number: 90-2837)  (Peer Review Approval 11/20/1989A )
      Toxicology and Carcinogenesis Studies of Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 30, 60, M: 0, 50, 100, 175 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0093)  Completed 
    • Citation: Effect of Dose on the Chemical Disposition of Furfural in Rats after Oral Administration.
    • Male Rats
    • Dose: 0.127, 1.15, 12.5 MG/KG.
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0370)  Completed 
    • Citation: Nomeir AA, Silveira DM, McComish MF, Chadwick M. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug Metab Dispos. 1992 Mar-Apr;20(2):198-204.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0763)  Completed 
    • Citation: Burka LT, Washburn KD, Irwin RD. Disposition of [14C] furan in the male F344 rat. J Toxicol Environ Health. 1991 Oct;34(2):245-57.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (991433)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (384163)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (778815)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (686415)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Salmonella  (363791)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (549472)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Equivocal 
  • Salmonella  (901759)  Completed 
    •  Equivocal 
  • Sister Chromatid Exchanges  (991433)  Completed 
    • Mice
    • Sister Chromatid  Negative