National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10121-j

Testing Status of Furfuryl alcohol - 10121-J

 

CASRN: 98-00-0

Formula: C5-H6-O2

Synonyms/Common Names

  • 2-Furanmethanol (9CI)
  • Furylcarbinol
  • 2-Hydroxymethylfuran

Known Uses

Solvent for ethers and esters. In manufacture of phenolic and furan resins. Chemical intermediate. Wetting agent. Liquid propellant. Flavoring agent, obtained from processing corncobs, coffee beans. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C56224B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 16, 31, 63, 125 AND 250 PPM (5/S/S).
  • 13 weeks (Inhalation)  (C56224B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 2, 4, 8, 16 OR 32 PPM / (10/S/S).

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C56224C)  Report Complete 
    • TR-482 (NIH Number: 99-3972)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 2, 8, OR 32 PPM (50/SEX/SPECIES/GROUP).

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0094)  Completed 
    • Citation: Nomeir AA, Silveira DM, McComish MF, Chadwick M. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug Metab Dispos. 1992 Mar-Apr;20(2):198-204.Pubmed Abstract
    • Male Rats: F344/N
  • Toxicokinetic Study (Inhalation)  (S0781)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: 0, 2, 8, & 32 ppm.

Genetic Toxicology

  • Chromosome Aberrations  (150910)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (799233)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • Micronucleus  (A08423)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (709717)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (150910)  Completed 
    • Mice
    • Sister Chromatid  Negative 
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