Testing Status of HC Yellow 4 10123-S

 

CASRN: 59820-43-8

Formula: C10-H14-N2-O5

Synonyms/Common Names

  • 2-((2-(2-Hydroxyethoxy)-4-nitrophenyl)amino)ethanol
  • Yellow 4, HC

Known Uses

In semi-permanent hair dye formulations (HSDB 1990).

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C56019)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C56019)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 2500, 20000 M: 0, 5000, 80000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56019)  Report Complete 
    • TR-419 (NIH Number: 92-3150)  (Peer Review Approval 07/09/1991A )
      Toxicology and Carcinogenesis Studies of HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: MR: 0, 0.25, 0.5%, FR&M: 0, 0.5, 1.0%/70 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (203825)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (048811)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Salmonella  (764380)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive