National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10124-w

Testing Status of Hexachloro-1,3-butadiene - 10124-W

 

CASRN: 87-68-3

Formula: C4-Cl6

Synonyms/Common Names

  • 1,3-Butadiene, 1,1,2,3,4,4,-hexachloro- (8CI)(9CI)

Known Uses

Solvent for elastomers; heat-transfer liquid; hydraulic fluid; rubber intermediate; fumigant for grapes (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C99854A)  Completed 
    • Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C99854A)  Report Complete 
    • TOX-01 (NIH Number: 91-3120)
      Toxicity Studies of Hexachloro-1,3-butadiene in B6C3F1 Mice (Feed Studies) (CASRN 87-68-3)
    • Mice: B6C3F1
    • Dose: MICE ONLY 0, 1, 3, 10, 30, 100 PPM.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0071)  Completed 
    • Male Rats; Male Mice; Male Rats; Male Mice
    • Dose: R:0.58-34 MG/KG; M: 2-24 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (635625)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (812114)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (098967)  Completed 
    •  Negative 
  • Salmonella  (358791)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 17 GD - PND 10 Conventional Teratology (Dosed-Feed)  (T0166)  Completed 
    • Citation: Final Report of the Peri-/Postnatal Evaluation of Hexachloro-1,3-Butadiene (HCBD) Toxicity in CD Rats
    • Female Rats: Sprague Dawley
    • Dose: 0, 100, 200, 400, 750, 1100, OR 1500 PPM.
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