Testing Status of Hexachlorocyclopentadiene 10125-A


CASRN: 77-47-4

Formula: C5-Cl6

Synonyms/Common Names

  • 1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene (9CI)
  • Perchlorocyclopentadiene

Known Uses

Chemical used in the manufacture of flame retardants, resins, and chlorinated cyclodiene pesticides.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C55607B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 0.05, 2.0 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55607B)  Report Complete 
    • TR-437 (NIH Number: 94-3168)  (Peer Review Approval 06/22/1993A )
      Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R:0, .01, .05, .2PPM M:0, .01, .05, .2, .5PPM/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Inhalation; Intravenous)  (S0029)  Completed 
    • Citation: el Dareer SM, Noker PE, Tillery KF, Hill DL. Investigations on the basis for the differential toxicity of hexachlorocyclopentadiene administered to rats by various routes. J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):203-11.Pubmed Abstract
    • Male Rats: F344/N; Male Rats; Male Rats: F344/N
    • Dose: PO:4.1, 61; IV:0.59; INH:1.3 (6H), 1.8(72H)MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (353427)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (386002)  Completed 
    • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (842404)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A24947)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (725996)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (A66714)  Completed 
    •  Negative