Testing Status of Hexachloroethane 10126-E

 

CASRN: 67-72-1

Formula: C2-Cl6

Synonyms/Common Names

  • Carbon hexachloride

Known Uses

Solvent, in explosives, camphor substitute in celluloid, in production of metals, antihelmintic drug, moth repellant, rubber vulcanizing, flame proofing (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04604A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 14-Day (Gavage)  (C04604B)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C04604A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 178, 1780, M: 0, 316, 3160 MG/KG/5 PER GROUP.
  • 13-Week (Gavage)  (C04604B)  Completed 
    • Rats: F344/N
    • Dose: 0, .047, .750 G/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04604A)  Report Complete 
    • TR-068 (NIH Number: 78-1318)  (Peer Review Approval 01/18/1978A )
      Bioassay of Hexachloroethane for Possible Carcinogenicity (CASRN 67-72-1)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 212, 423 M:0, 590, 1179 MG/KG/50 PER GROUP.
  • 2 years (Gavage)  (C04604B)  Report Complete 
    • TR-361 (NIH Number: 89-2816)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats No Evidence 
    • Dose: MR: 0, 10, 20, FR: 0, 80, 160 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (415312)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (188925)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (248997)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative