Testing Status of Isoproterenol hydrochloride 10130-N

 

CASRN: 51-30-9

Formula: C11-H17-N-O3.Cl-H

Synonyms/Common Names

  • 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, hydrochloride (9CI)

Known Uses

Bronchodilator

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (968791)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Salmonella  (838263)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (973172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Intraperitoneal Injection)  (TER82088)  Completed 
    • Citation: Teratologic Evaluation of Isoproterenol Hydrochloride in CD Rats
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 20, 40, 80 MG/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Subcutaneous Injection)  (TER90089)  Completed 
    • Citation: Toxicologic Evaluation of Isoproterenol Hydrochloride Administered Subcutaneously to CD Rats
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0.25, 0.50, 1.0, 5.0, 10, 20 MG/KG/DAY.