National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10135-h

Testing Status of Methapyrilene - 10135-H

 

CASRN: 91-80-5

Related: METHAPYRILENE HYDROCHLORIDE 135-23-9

Formula: C14-H19-N3-S

Synonyms/Common Names

  • N,N-dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-1,2-ethanediamine (9CI)

Known Uses

Antihistamine

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Cell Proliferation (Dosed-Feed)  (S0550)  Completed 
    • Citation: Cunningham ML, Pippin LL, Anderson NL, Wenk ML. The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. Toxicol Appl Pharmacol. 1995 Apr;131(2):216-23.Pubmed Abstract
    • Male Rats
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