National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10136-l

Testing Status of Methyl coumarin - 10136-L

 

CASRN: 92-48-8

Formula: C10-H8-O2

Synonyms/Common Names

  • 6-Methyl-2H-1-benzopyran-2-one (9CI)

Known Uses

Use in perfumes and flavoring agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55812)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55812)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 75, 1200, M: 0, 50, 800 MG/KG/10 PER GROUP.

Genetic Toxicology

  • Micronucleus  (A08341)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (644172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.