National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10138-v

Testing Status of Monochloroacetic acid - 10138-V

 

CASRN: 79-11-8

Formula: C2-H3-Cl-O2

Synonyms/Common Names

  • Acetic acid, chloro- (8CI)(9CI)

Known Uses

Chemical intermediate in the manufacture of various dyes and other organic materials. A postemergence contact herbicide.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C60231)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C60231)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 30, 150, M: 0, 25, 200 MG/KG/40 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60231)  Report Complete 
    • TR-396 (NIH Number: 92-2851)  (Peer Review Approval 11/20/1990A )
      Toxicology and Carcinogenesis Studies of Monochloroacetic Acid (CASRN 79-11-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 15, 30; M: 0, 50, 100 MG/KG/70 & 60 PER GROUP RESPECTIVELY.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (265221)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (255229)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Mouse Lymphoma  (486223)  Completed 
    • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
    • Mice
    •  Positive 
  • Salmonella  (910172)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (A15096)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.