National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10141-a

Testing Status of Nitrobenzene - 10141-A

 

CASRN: 98-95-3

Formula: C6-H5-N-O2

Synonyms/Common Names

  • Oil of mirbane

Known Uses

Used in production of pesticides, rubber chemicals, dyes, pharmaceuticals, in soaps, shoe polish, spray paint. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Topical Application)  (C60082B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Topical Application)  (C60082B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,0.05,0.08 G/KG/10 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (694968)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (193955)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (542172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM95003)  Completed 
    • Citation: Burns LA, Bradley SG, White KL Jr, McCay JA, Fuchs BA, Stern M, Brown RD, Musgrove DL, Holsapple MP, Luster MI, Munson, AE. Immunotoxicity of nitrobenzene in female B6C3F1 mice. Drug Chem Toxicol. 1994;17(3):271-315.
    • Female Mice: B6C3F1
    • Dose: 0, 30, 100, AND 300 MG/KG.
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