National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10142-e

Testing Status of p-Nitrophenol - 10142-E

 

CASRN: 100-02-7

Formula: C6-H5-N-O3

Synonyms/Common Names

  • 4-Nitrophenol (9CI)

Known Uses

Intermediate for insecticides. Azo and sulfur dyes. Leather preservatives, fungicide (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C55992B)  Report Complete 
    • TR-417 (NIH Number: 93-3148)  (Peer Review Approval 07/09/1991A )
      Toxicology and Carcinogenesis Studies of p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice (Dermal Studies)
    • Mice: Swiss Webster
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 40, 80, 175 MG/KG/60 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (333983)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Drosophila  (295493)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (616176)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (158764)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0047)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 400 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.