Testing Status of Pentaerythritol tetranitrate 10150-E

 

CASRN: 78-11-5

Formula: C5-H8-N4-O12

Synonyms/Common Names

  • 2,2-Bis((nitrooxy)-methyl)-1,3-propanediol dinitrate(ester) (9CI)

Known Uses

In detonating fuses; vasodilator

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55743)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55743)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .31, 5 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55743)  Report Complete 
    • TR-365 (NIH Number: 89-2820)  (Peer Review Approval 10/04/1988A )
      Toxicology and Carcinogenesis Studies of Pentaerythritol Tetranitrate (CASRN 78-11-5) with 80% D-Lactose Monohydrate (PETN, NF) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: FR: 0, 6200, 12500, MR&M: 0, 25000, 50000 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (896240)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (388086)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative