Testing Status of Picloram 10155-Y

 

CASRN: 1918-02-1

Formula: C6-H3-Cl3-N2-O2

Synonyms/Common Names

  • 4-Amino-3,5,6-trichloro-2-pyridinecarboxylic acid (9CI)

Known Uses

Herbicide

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00237A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00237A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 1250, 20000 (AVG), M: 0, 1250, 30000 (AVG) PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00237A)  Report Complete 
    • TR-023 (NIH Number: 78-823)  (Peer Review Approval 09/26/1977A )
      Bioassay of Picloram for Possible Carcinogenicity (CASRN 1918-02-1)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 7437, 14875 (AVG), M: 0, 2531, 5062 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (048749)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (627427)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Salmonella  (244865)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative