National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10160-l

Testing Status of Probenecid - 10160-L

 

CASRN: 57-66-9

Formula: C13-H19-N-O4-S

Synonyms/Common Names

  • 4-((Dipropylamino)sulfonyl)benzoic acid (9CI)

Known Uses

Uricosuric agent for treatment of gout and gouty arthritis. Probenecid is also used as a therapeutic adjunct to enhance blood levels of penicillin and its action.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56097)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56097)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, .05, .8, M: 0, .1, 1.6 G/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56097)  Report Complete 
    • TR-395 (NIH Number: 91-2850)  (Peer Review Approval 11/20/1990A )
      Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M:0, 100, 400 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (722868)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (518172)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0007A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 1200 MG/KG BODY WEIGHT.
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0007B)  Completed 
    • Female Mice: Swiss
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