National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10163-y

Testing Status of Resorcinol - 10163-Y

 

CASRN: 108-46-3

Related: TRANSGENIC MODEL EVALUATION (RESORCINOL)

Formula: C6-H6-O2

Synonyms/Common Names

  • 1,3-Benezenediol (9CI)

Known Uses

Tanning, chemical production, dyes, cosmetics, pharmaceuticals, photography, intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C05970A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C05970A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 32, 520, M: 0, 28, 420 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C05970A)  Report Complete 
    • TR-403 (NIH Number: 92-2858)  (Peer Review Approval 03/11/1991A )
      Toxicology and Carcinogenesis Studies of Resorcinol (CASRN 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: MR&M: 0, 112, 225 FR: 0, 50, 100, 150 MG/KG/60 PER GROUP.

Special Studies

  • Metabolism  (S0713)  Completed 
    • Citation: Kim YC, Matthews HB. Comparative metabolism and excretion of resorcinol in male and female F344 rats. Fundam Appl Toxicol. 1987 Oct;9(3):409-14.Pubmed Abstract
    • Male and Female Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (101147)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (126256)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Mouse Lymphoma  (743596)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Micronucleus  (A90027)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (674324)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
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