National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10166-k

Testing Status of Styrene - 10166-K

 

CASRN: 100-42-5

Formula: C8-H8

Synonyms/Common Names

  • Ethenylbenzene (9CI)
  • Phenylethylene
  • Vinylbenzene

Known Uses

In manufacture of plastics, synthetic rubber, resins. Insulator. Used in construction materials and boats. Chemical intermediate. Flavoring agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C02200A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 2 weeks (Inhalation)  (C02200B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 30, 100, 300, 1000, 0R 2000 PPM (5/S/S).
  • 13-Week (Gavage)  (C02200A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,681,3160, M: 0,147,681 MG/KG/10 PER GROUP.
  • 13 weeks (Inhalation)  (C02200B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 125, 250, 500, 1000, OR 1500 PPM M: 0, 62.5, 125, 250, OR 500 PPM.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C02200A)  Report Complete 
    • TR-185 (NIH Number: 79-1741)  (Peer Review Approval 10/25/1978A )
      Bioassay of Styrene for Possible Carcinogenicity (CASRN100-42-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Negative 
    • Dose: R: 0,500,1000,2000, M: 0,150,300 MG/KG/50 PER GROUP.

Special Studies

  • Mechanisms (Inhalation)  (S0333)  Completed 
    • Citation: Mahler JF, Price HC Jr, O'Connor RW, Wilson RF, Eldridge SR, Moorman MP, Morgan DL. Characterization of hepatocellular resistance and susceptibility to styrene toxicity in B6C3F1 mice. Toxicol Sci. 1999 Mar;48(1):123-33. Pubmed Abstract
    • Citation: Morgan DL, Mahler JF, Dill JA, Price HC Jr, O'Connor RW, Adkins B Jr. Styrene inhalation toxicity studies in mice. II. Sex differences in susceptibility of B6C3F1 mice. Fundam Appl Toxicol. 1993 Oct;21(3):317-25. Pubmed Abstract
    • Citation: Morgan DL, Mahler JF, Dill JA, Price HC Jr, O'Connor RW, Adkins B Jr. Styrene inhalation toxicity studies in mice. III. Strain differences in susceptibility. Fundam Appl Toxicol. 1993 Oct;21(3):326-33.Pubmed Abstract
    • Male and Female Mice: B6C3F1; Male and Female Mice: C57BL/6; Male and Female Mice: Swiss; Male and Female Mice
    • Dose: 125, 250 OR 500 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (987609)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (173117)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (N-9246)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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