National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10167-p

Testing Status of Talc - 10167-P

 

CASRN: 14807-96-6

Formula: H2-O3-Si.3/4Mg

Synonyms/Common Names

  • Agalite

Known Uses

Dusting powder for medicinal and cosmetic preparations. Excipient and filler for pills. Used by rubber, paint, food, asphalt, and paper industries. Improves thermoforced food packaging. Occurs naturally.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C06008)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C06008)  Report Complete 
    • TR-421 (NIH Number: 93-3152)  (Peer Review Approval 06/23/1992A )
      Toxicology and Carcinogenesis Studies of Talc (CASRN 14807-96-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R & M: 0, 6, AND 18 MG OF TALC/M3 OF ATMOSPHERE.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.