National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10171-y

Testing Status of Tetrakis(hydroxymethyl)phosphonium chloride - 10171-Y

 

CASRN: 124-64-1

Formula: C4-H12-O4-P.Cl

Synonyms/Common Names

  • Phosphonium, tetrakis(hydroxymethyl)-, chloride
  • THPC

Known Uses

Flame retardant for textiles. Broad spectrum disinfectant. Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C55061)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 9.4, 10.8, 37.5, 75, 150 MG/KG; M: 0, 18.8, 37.5, 75, 150, 300 MG/KG.
  • 13 weeks (Gavage)  (C55061)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 3.75, 7.5, 15, 30, 60 MG/KG; M: 0, 1.5, 4.5, 15, 45, 135 MG/KG 10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55061)  Report Complete 
    • TR-296 (NIH Number: 87-2552)  (Peer Review Approval 03/26/1986A )
      Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN 55566-30-8) and Tetrakis(hydroxymethyl)phosphonium chloride (THPC) (CASRN 124-64-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 3.75, 7.5, MM: 0, 7.5, 15, FM: 0, 15, 30 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (523400)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (824859)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (A09015)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (778372)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage)  (NTA94017)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Female Rats: F344/N
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