Testing Status of Titanocene dichloride 10174-K

 

CASRN: 1271-19-8

Formula: C10-H10-Cl2-Ti

Synonyms/Common Names

  • Dichlorobis(eta(5)-2,4-cyclopentadien-1-yl)-titanium (9CI)

Known Uses

It is used as a cocatalyst in polymerization reactions. Research chemical. Catalyst.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04502)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C04502)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, .008, .125 G/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C04502)  Report Complete 
    • TR-399 (NIH Number: 91-2854)  (Peer Review Approval 11/19/1990A )
      Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
    • Dose: RATS ONLY:0, 25, 50 MG/KG/80 PER GROUP.

Special Studies

  • Toxicokinetic Study  (S0269)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (241636)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (813172)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (N-9026)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251