National Toxicology Program

National Toxicology Program

Testing Status of Tris(2-Chloroethyl) Phosphate - 10178-C


CASRN: 115-96-8

Formula: C6-H12-Cl3-O4-P

Synonyms/Common Names

  • 2-Chloroethanol phosphate (3:1) (9CI)

Known Uses

Flame retardant. Plasticizer.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C60128)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Gavage)  (C60128)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,22,350; M: 0,44,700 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60128)  Report Complete 
    • TR-391 (NIH Number: 91-2846)  (Peer Review Approval 04/25/1990A )
      Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CASRN 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0,44,88; M: 0,175,350 MG/KG/60 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0183)  Completed 
    • Citation: Disposition of Tris (2-Chloroehtyl) Phosphate(TRCP) in Rats after Oral Administration, March, 1988.
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination  (S0723)  Completed 
    • Citation: Herr DW, Sanders JM, Matthews HB. Brain distribution and fate of tris(2-chloroethyl) phosphate in Fischer 344 rats. Drug Metab Dispos. 1991 Mar-Apr;19(2):436-42.Pubmed Abstract
    • Male and Female Rats: F344/N
  • Metabolism (Gavage)  (S0107)  Completed 
    • Citation: Burka LT, Sanders JM, Herr DW, Matthews HB. Metabolism of tris(2-chloroethyl) phosphate in rats and mice. Drug Metab Dispos. 1991 Mar-Apr;19(2):443-7. Burka LT, Sanders JM, Herr DW, Matthews HB. Metabolism of tris(2-Chloroethyl) phosphate in rats & mice. Drug Metab Dispo. 1991;19(2): 443-447.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
  • Metabolism  (S0724)  Completed 
    • Citation: Chapman DE, Michener SR, Powis G. Metabolism of the flame retardant plasticizer tris(2-chloroethyl)phosphate by human and rat liver preparations. Fundam Appl Toxicol. 1991 Aug;17(2):215-24.Pubmed Abstract
    • Rats: F344/N; Human (Cell Lines)
  • Other (Gavage)  (S0495)  Completed 
    • Citation: Tilson HA, Veronesi B, McLamb RL, Matthews HB. Acute exposure to tris(2-chloroethyl)phosphate produces hippocampal neuronal loss and impairs learning in rats. Toxicol Appl Pharmacol. 1990 Nov;106(2):254-69.Pubmed Abstract
    • Female Rats: F344/N
  • Other  (S0725)  Completed 
    • Citation: Deterding LJ, Dix K, Burka LT, Tomer KB. On-line coupling of in vivo micro dialysis with tandem mass spectrometry. Anal Chem. 1992 Nov 1;64(21):2636-41.Pubmed Abstract
    • Male Rats: F344/N
  • Other (in-vitro)  (S0823)  Completed 
    • Citation: Special Study on Serum Cholinesterase Levels during the 90 Day Subchronic Toxicity Test Tris (2-Chloroethyl) Phosphate in Fischer 344 Rats.
    • Male and Female Rats: F344/N
  • C. elegans  (W10178)  Completed 
    • C. elegans

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (616376)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Salmonella  (639784)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Gavage)  (RACB92040)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Tris(2-Chloroethyl)phosphate in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0,87.5,175,350,700,1000; 0,175,350,700 MG/KG/DAY; 0,700 MG/KG/DAY; 0,175,350,700 MG/KG/DAY.
  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0085)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 940 MG/KG BODY WT.
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