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Testing Status of Tris(2-Chloroethyl) Phosphate 10178-C

 

CASRN: 115-96-8

Formula: C6-H12-Cl3-O4-P

Synonyms/Common Names

  • 2-Chloroethanol phosphate (3:1) (9CI)

Known Uses

Flame retardant. Plasticizer.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C60128)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Gavage)  (C60128)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 22, 350; M: 0, 44, 700 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60128)  Completed 
    • TR-391 (NIH Number: 91-2846)  (Peer Review Approval 04/25/1990A )
      Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CASRN 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0, 44, 88; M: 0, 175, 350 MG/KG/60 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0183)  Completed 
    • Citation: Disposition of Tris (2-Chloroehtyl) Phosphate(TRCP) in Rats after Oral Administration, March, 1988.
    • Male Rats: F344/N
    • Dose: 88 MG/KG.
  • Absorption Disposition Metabolism Elimination  (S0723)  Completed 
    • Citation: Herr DW, Sanders JM, Matthews HB. Brain distribution and fate of tris(2-chloroethyl) phosphate in Fischer 344 rats. Drug Metab Dispos. 1991 Mar-Apr;19(2):436-42.Pubmed Abstract
    • Male and Female Rats: F344/N
  • Metabolism (Gavage)  (S0107)  Completed 
    • Citation: Burka LT, Sanders JM, Herr DW, Matthews HB. Metabolism of tris(2-chloroethyl) phosphate in rats and mice. Drug Metab Dispos. 1991 Mar-Apr;19(2):443-7. Burka LT, Sanders JM, Herr DW, Matthews HB. Metabolism of tris(2-Chloroethyl) phosphate in rats & mice. Drug Metab Dispo. 1991;19(2): 443-447.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 175 MG/KG.
  • Metabolism  (S0724)  Completed 
    • Citation: Chapman DE, Michener SR, Powis G. Metabolism of the flame retardant plasticizer tris(2-chloroethyl)phosphate by human and rat liver preparations. Fundam Appl Toxicol. 1991 Aug;17(2):215-24.Pubmed Abstract
    • Rats: F344/N; Human (Cell Lines)
  • Other (Gavage)  (S0495)  Completed 
    • Citation: Tilson HA, Veronesi B, McLamb RL, Matthews HB. Acute exposure to tris(2-chloroethyl)phosphate produces hippocampal neuronal loss and impairs learning in rats. Toxicol Appl Pharmacol. 1990 Nov;106(2):254-69.Pubmed Abstract
    • Female Rats: F344/N
    • Dose: 275 MG/KG.
  • Other  (S0725)  Completed 
    • Citation: Deterding LJ, Dix K, Burka LT, Tomer KB. On-line coupling of in vivo micro dialysis with tandem mass spectrometry. Anal Chem. 1992 Nov 1;64(21):2636-41.Pubmed Abstract
    • Male Rats: F344/N
  • Other (in-vitro)  (S0823)  Completed 
    • Citation: Special Study on Serum Cholinesterase Levels during the 90 Day Subchronic Toxicity Test Tris (2-Chloroethyl) Phosphate in Fischer 344 Rats.
    • Male and Female Rats: F344/N
  • C. elegans  (W10178)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: Growth: 0, 100, 130, 160, 200, 250, 320, 400, 500, 630, 790, 1000uMRepro: 0, 100, 130, 160, 200, 250, 320, 400, 500, 630, 790, 1000uMFeeding: 0, 100, 130, 160, 200, 250, 320, 400, 500, 630, 790, 1000uM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (616376)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Salmonella  (639784)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Gavage)  (RACB92040)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Tris(2-Chloroethyl)phosphate in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0, 87.5, 175, 350, 700, 1000; 0, 175, 350, 700 MG/KG/DAY; 0, 700 MG/KG/DAY; 0, 175, 350, 700 MG/KG/DAY.
  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0085)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 940 MG/KG BODY WT.