National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10179-f

Testing Status of 4-Vinyl-1-cyclohexene diepoxide - 10179-F

 

CASRN: 106-87-6

Formula: C8-H12-O2

Synonyms/Common Names

  • 3-Oxiranyl-7-oxabicyclo(4.1.0)heptane (9CI)
  • Vinylcyclohexene diepoxide
  • 1-Vinyl-3-cyclohexene dioxide

Known Uses

Organic synthesis. Reactive diluent. Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Topical Application)  (C60139A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Topical Application)  (C60139A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 62.5, 1000 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C60139A)  Report Complete 
    • TR-362 (NIH Number: 90-2817)  (Peer Review Approval 03/13/1989A )
      Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CASRN 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 50, 100, M: 0, 25, 50, 100 MG/ML/60 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application)  (S0138)  Completed 
    • Male and Female Rats; Male and Female Mice; Male and Female Rats; Male and Female Mice
    • Dose: R: .15, 30 MG/RAT M: 0, 2.5, 5, 10 MG/MOUSE.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (629851)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (496867)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (708500)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.