National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10180-d

Testing Status of Vinylidene fluoride - 10180-D

 

CASRN: 75-38-7

Formula: C2-H2-F2

Synonyms/Common Names

  • 1,1-Difluoroethene

Known Uses

Manufacture of polymers or copolymers. Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C60208A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C60208A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 500, 50000 PPM/10 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0224)  Completed 
    • Citation: Bechtold WE, Medinsky MA, Gerlach RF. The determination of a volatile gas, vinylidene fluoride, in blood during a nose-only exposure. J Anal Toxicol. 1988 Mar-Apr;12(2):62-6.Pubmed Abstract
    • Citation: Medinsky MA, Bechtold WE, Birnbaum LS, Chico DM, Gerlach RF, Henderson RF. Uptake of vinylidene fluoride in rats simulated by a physiological model. Fundam Appl Toxicol. 1988 Aug;11(2):250-60. Pubmed Abstract
    • Citation: Medinsky MA, Bechtold WE, Birnbaum LS, Henderson RF. Measurement of steady-state blood concentrations in B6C3F1 mice exposed by inhalation to vinylidene fluoride. Toxicology. 1990 Dec 3;64(3):255-63. Pubmed Abstract
    • Rats; Mice
    • Dose: 250, 3750 & 15, 000 PPM.

Genetic Toxicology

  • Salmonella  (064436)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.