National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10184-t

Testing Status of Sodium xylenesulfonate - 10184-T

 

CASRN: 1300-72-7

Formula: C8-H10-O3-S.Na

Synonyms/Common Names

  • Dimethylbenzenesulfonic acid sodium salt (9CI)
  • Xylene sulfonic acid, Na Salt

Known Uses

Hydrotrope in liquid detergents, shampoos, degreasing compounds. Used in textile, paper, and leather industries.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 3 weeks (Topical Application)  (C55403C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Topical Application)  (C55403C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 120.0, 39.9, 13.2, 4.5, 1.5, 0 MG/KG.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C55403D)  Report Complete 
    • TR-464 (NIH Number: 98-3380)  (Peer Review Approval 12/05/1995A )
      Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylene Sulfonate (CASRN 1300-72-7) in F344 Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 60, 120, OR 240 MG/KG M: 0, 182, 364, OR 727 MG/KG (50/SEX/GROUP).

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (344381)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (779152)  Completed 
    • Mice
    •  Equivocal 
  • Salmonella  (994691)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.