National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10185-x

Testing Status of 2,6-Xylidine - 10185-X

 

CASRN: 87-62-7

Formula: C8-H11-N

Synonyms/Common Names

  • 2,6-Dimethylaniline (2-DMA)
  • 2,6-Dimethylbenzenamine (9CI)

Known Uses

Chemical intermediate for dyes and a metabolite of certain drugs, particularly the xylide group of local anesthetics. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 10 & 14 weeks (Dosed-Feed)  (C56188B)  Completed 
    • Rats: CD
    • Dose: SD(GAV):0.215,0.316, 0.681,1,1.47,2.15, 3.16 MG/KG IN CORN OIL/ 5 PER GROUP; SC (FEED): 0,100,300, 1000,3000,10000 PPM (MALES 10 WKS, FEMALES 14 WKS).

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56188B)  Report Complete 
    • TR-278 (NIH Number: 90-2534)  (Peer Review Approval 09/22/1982A )
      Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in Charles River CD Rats (Feed Studies)
    • Rats: CD
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
    • Dose: 0,300,1000,3000 PPM/56 ANIMALS PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (852885)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (538744)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (976601)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (112391)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Weakly Positive 
  • Salmonella  (593478)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Weakly Positive 
  • Salmonella  (818172)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.