Testing Status of 1,2,3-Trichloropropane 10186-C

 

CASRN: 96-18-4

Formula: C3-H5-Cl3

Synonyms/Common Names

  • Allyl trichloride

Known Uses

Paint and varnish remover. Solvent. Degreasing agent. Intermediate for polysulfide liquid polymers.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Gavage)  (C60220A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 8, 250 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60220B)  Report Complete 
    • TR-384 (NIH Number: 94-2839)  (Peer Review Approval 07/09/1991A )
      Toxicology and Carcinogenesis Studies of 1,2,3-Trichloropropane (CASRN 96-18-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 3, 10, 30, M: 0, 6, 20, 60 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0670)  Completed 
    • Citation: Pharmacokinetics of Xenobiotics: 1,2,3-Trichloropropane
    • Male Rats: F344/N
    • Dose: Gavage: 0.35, 3.0, and 32 mg/kg [2.4, 20, and 220 umol/kg] IV: 3.6 mg/kg [approx. 14uCi/mg].
  • Absorption Disposition Metabolism Elimination  (S0671)  Completed 
    • Citation: Metabolism and Mechanism of 1,2,3-trichloropropane Interaction with Macromolecular Molecules. Final report November 29, 1988; Annual Report May 5, 1989: Annual Report 1989-1990, October 29, 1990.
    • Male Rats: F344/N
    • Dose: 30 mg/kg.
  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0705)  Completed 
    • Citation: Volp RF, Sipes IG, Falcoz C, Carter DE, Gross JF. Disposition of 1,2,3-trichloropropane in the Fischer 344 rat: conventional and physiological pharmacokinetics. Toxicol Appl Pharmacol. 1984 Aug;75(1):8-17.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 3.6 mg [0.024 mmol]/kg.
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0706)  Completed 
    • Citation: Mahmood NA, Overstreet D, Burka LT. Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice. Drug Metab Dispos. 1991 Mar-Apr;19(2):411-8.Pubmed Abstract
    • Male and Female Rats: F344/N; Male Mice: B6C3F1
    • Dose: 30 mg/kg in rats; 30 and 60 mg/kg in mice.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (539595)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (544452)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (137369)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (600157)  Completed 
    •  Positive 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Gavage)  (RACB91039)  Completed 
    • Citation: 1,2,3-Trichloropropane: Reproduction and Fertility Assessment in Swiss CD-1 Mice when Administered by Gavage
    • Male and Female Mice: Swiss
    • Dose: 0, 12.5, 25, 50, 100, 200 MG/KG; 0, 30, 60, 120 MG/KG/DAY; 0, 120 MG/KG; 0, 30, 60, 120 MG/KG.