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Testing Status of n-Hexane 10189-N

 

CASRN: 110-54-3

Formula: C6-H14

Synonyms/Common Names

  • Hexane (8CI)(9CI)

Known Uses

Determination of refractive index of minerals, calibrations, reaction medium, solvent, alcohol denaturant, pharmaceuticals, paint diluent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C60571)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 500, 1000, 4000, 10000PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (587411)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A42410)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (701057)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (699016)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • 5 consecutive days Dominant Lethal (Inhalation)  (T0185B)  Completed 
    • Citation: Inhalation Reproductive Toxicology Studies: Male Dominant Lethal Study of N-Hexane in Swiss (CD-1) Mice (August 1988)
    • Male Mice: Swiss
    • Dose: 200, 1000, 5000 PPM; 20 HR/DAY.
  • Neurotoxicology Assessment (Inhalation)  (NTA94015)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats/Mice: F344/N
  • 6 to 19 GD Conventional Teratology (Inhalation)  (TER90082)  Completed 
    • Citation: Inhalation Developmental Toxicology Studies: Teratology Study of N-Hexane in Rats (December 1987)
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 200, 1000, 5000 PPM.
  • 6 to 17 GD Conventional Teratology (Inhalation)  (TER90083)  Completed 
    • Citation: Inhalation Developmental Toxicology Studies: Teratology Study of n-Hexane in Mice
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 200, 1000, 5000 PPM.