National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10190-k

Testing Status of Ethylenediamine - 10190-K

 

CASRN: 107-15-3

Formula: C2-H8-N2

Synonyms/Common Names

  • 1,2-Ethanediamine (9CI)

Known Uses

In preparation of dyes, medication, urinary acidifier, carbamate fungicides, textile lubricants, pharmaceutical aid, solvent for casein.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Drosophila  (140628)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (101009)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Salmonella  (414798)  Completed 
    •  Positive 
  • Salmonella  (477362)  Completed 
    •  Equivocal 
  • Salmonella  (572096)  Completed 
    •  Positive 
  • Salmonella  (756389)  Completed 
    •  Weakly Positive 
  • Salmonella  (942194)  Completed 
    •  Positive 
  • Salmonella  (986505)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application & Subcutaneous Injection)  (IMM91018)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 1, 3, 10%.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0060)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 400 MG/KG BD WT.
  • Conventional Teratology (Gavage)  (TER92020)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Ethylenediamine in New Zealand White Rabbits
    • Rabbit: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 0, 10, 40, 80 MG/KG/DAY.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP91009)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 100, 400, 600, 750, OR 900 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.