Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Ethylenediamine 10190-K

 

CASRN: 107-15-3

Formula: C2-H8-N2

Synonyms/Common Names

  • 1,2-Ethanediamine (9CI)

Known Uses

In preparation of dyes, medication, urinary acidifier, carbamate fungicides, textile lubricants, pharmaceutical aid, solvent for casein.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Drosophila  (140628)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (101009)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Salmonella  (414798)  Completed 
    •  Positive 
  • Salmonella  (477362)  Completed 
    •  Equivocal 
  • Salmonella  (572096)  Completed 
    •  Positive 
  • Salmonella  (756389)  Completed 
    •  Weakly Positive 
  • Salmonella  (942194)  Completed 
    •  Positive 
  • Salmonella  (986505)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application & Subcutaneous Injection)  (IMM91018)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 1, 3, 10%.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0060)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 400 MG/KG BD WT.
  • Conventional Teratology (Gavage)  (TER92020)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Ethylenediamine in New Zealand White Rabbits
    • Rabbit: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 0, 10, 40, 80 MG/KG/DAY.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP91009)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 100, 400, 600, 750, OR 900 MG/KG.