National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10195-f

Testing Status of Doxylamine - 10195-F

 

CASRN: 469-21-6

Formula: C17-H22-N2-O

Synonyms/Common Names

  • N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine

Known Uses

Used as sedative, hypnotic, antihistamine and antitussive.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C60684)  Completed 
    • NR-406/407  (Peer Review Approval NA)
      Chronic Study of Doxylamine in Fischer 344 Rats and B6C3F1 Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C60684)  Completed 
    • NR-406/407
      Chronic Study of Doxylamine in Fischer 344 Rats and B6C3F1 Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,162,6325, M: 0,80,1500 PPM/24 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C60684)  Report Complete 
    • NR-406/407  (Peer Review Approval NA)
      Chronic Study of Doxylamine in Fischer 344 Rats and B6C3F1 Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,500,1000,2000, M: 0,190,375,750 PPM/50 PER GROUP.
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