Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Cobalt 10204-K


CASRN: 7440-48-4

Formula: Co

Synonyms/Common Names

  • Cobalt, elemental
  • Cobalt metal

Known Uses

Nuclear medicine and research, industry, paints, water treatment, metallurgy (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C60311)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 2.5, 5, 10, 20, or 40 mg/m3; 5/sex/species/dose.
  • 13 weeks (Inhalation)  (C60311)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 0.625, 1.25, 2.5, or 5.0 mg/m3; 20/sex/dose M: 0, 0.625, 1.25, 2.5, 5.0, or 10 mg/m3; 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C60311)  Completed 
    • TR-581 (NIH Number: 15-5923)  (Peer Review Approval 10/29/2013A )
      Toxicology Studies of Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/N Mice (Inhalation Studies)
    • Rats: F344/NTac; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 1.25, 2.5, or 5 mg/m3; 50/sex/species/dose.

Genetic Toxicology

  • Micronucleus  (A57655)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A79569)  Completed 
    •  Positive