National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10204-k

Testing Status of Cobalt - 10204-K

 

CASRN: 7440-48-4

Related: COBALT SULFATE HEPTAHYDRATE (10026-24-1)

Formula: Co

Synonyms/Common Names

  • Cobalt, elemental
  • Cobalt metal

Known Uses

Nuclear medicine and research, industry, paints, water treatment, metallurgy (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C60311)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 2.5, 5, 10, 20, or 40 mg/m3; 5/sex/species/dose.
  • 13 weeks (Inhalation)  (C60311)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 0.625, 1.25, 2.5, or 5.0 mg/m3; 20/sex/dose M: 0, 0.625, 1.25, 2.5, 5.0, or 10 mg/m3; 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C60311)  Report Complete 
    • TR-581 (NIH Number: 15-5923)  (Peer Review Approval 10/29/2013A )
      Toxicology Studies of Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/N Mice (Inhalation Studies)
    • Rats: F344/NTac; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 1.25, 2.5, or 5 mg/m3; 50/sex/species/dose.

Genetic Toxicology

  • Micronucleus  (A57655)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A79569)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.