National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10205-p

Testing Status of Dimethyloldihydroxyethyleneurea - 10205-P

 

CASRN: 1854-26-8

Formula: C5-H10-N2-O5

Synonyms/Common Names

  • 4,5-Dihydroxy-1,3-bis(hydroxymethyl)-2-imidazolidinone
  • Dimethylolgloxalmonoureine

Known Uses

Used in cotton-containing textiles to impart durable-press properties to the fabric. Primary cross-linking agent used in US.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0196)  Completed 
    • Male Rats: F344/N
    • Dose: PO:502, 979, 1970; IV:50; DER:2, 24, 109, 133 MG/KG.
  • Toxicokinetic Study (Gavage; Intravenous; Topical Application)  (S0086)  Completed 
    • Male Rats: F344/N
    • Dose: IV: 48 MG/KG; ORAL: 502, 979 & 1970 MG/KG; DERMAL: 3.5 & 13 MG/CM2.

Genetic Toxicology

  • Drosophila  (284655)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Salmonella  (102209)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 
  • Salmonella  (499979)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
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