National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10206-t

Testing Status of N-Methylolacrylamide - 10206-T

 

CASRN: 924-42-5

Related: TRANSGENIC MODEL EVALUATION (N-METHOLOLACRYLAMIDE)

Formula: C4-H7-N-O2

Synonyms/Common Names

  • N-(Hydroxymethyl)-acrylamide (8CI)
  • N-(Hydroxymethyl)-2-propenamide (9CI)

Known Uses

Proposed for use in sunscreen preparations. Polymers for coating, varnishes, adhesives, crease-proof and wrinkle-resistant fabrics, permanent-press textiles by irradiation bonding.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C60333)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C60333)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 12.5, 200 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60333)  Report Complete 
    • TR-352 (NIH Number: 89-2807)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 6, 12, M: 0, 25, 50 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intraperitoneal Injection)  (S0817)  Completed 
    • Citation: Comparative Metabolism and Excretion of [14C]Hydroxymethylacrylamide in Male Rats and Mice. Studies of Chemical Disposition in Mammals. February 28, 2001
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 1.5 and 150 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (193375)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (081496)  Completed 
    • Citation: Witt KL, Hughes L, Burka LT, McFee A, Bishop JB. Mouse bone marrow micronucleus test results do not predict the germ cell mutagenicity of N-hydroxy-methylacrylamide in the mouse dominant lethal assay. Environ. Mol. Mutagen Vol. 41 (2003) 111-120
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A49398)  Completed 
    • Citation: Witt KL, Hughes L, Burka LT, McFee A, Bishop JB. Mouse bone marrow micronucleus test results do not predict the germ cell mutagenicity of N-hydroxy-methylacrylamide in the mouse dominant lethal assay. Environ. Mol. Mutagen Vol. 41 (2003) 111-120
    • Mice: C3H
    • Male Negative 
  • Micronucleus  (A92682)  Completed 
    • Citation: Witt KL, Hughes L, Burka LT, McFee A, Bishop JB. Mouse bone marrow micronucleus test results do not predict the germ cell mutagenicity of N-hydroxy-methylacrylamide in the mouse dominant lethal assay. Environ. Mol. Mutagen Vol. 41 (2003) 111-120
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (155882)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage)  (NTA94023)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats: F344/N
  • Continuous Breeding (Legacy) (Dosed-Water)  (RACB90017)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of N-(Hydroxymethyl)-Acrylamide (HACR) in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0, 60, 180, 360, 540, 720 PPM; 0, 60, 180, 360 PPM; 0, 360 PPM; 0, 60, 180, 360 PPM.
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