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Testing Status of Nickel sulfate hexahydrate 10207-X


CASRN: 10101-97-0

Formula: Ni-O4-S.6H2-O

Synonyms/Common Names

  • Sulfuric acid, nickel(2+) salt (1:1), hexahydrate

Known Uses

Nickel plating. Blackening zinc and brass. Mordant in dyeing and printing textiles. Manufacture of organic nickel salts.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C60344)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3.5, 7.0, 15.0, 30.0, OR 60.0 MG/M3; 5/GROUP.
  • 13 weeks (Inhalation)  (C60344)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.12, 0.25, 0.50, 1.0, OR 2.0 MG/M3.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C60344)  Completed 
    • TR-454 (NIH Number: 96-3370)  (Peer Review Approval 11/29/1994A )
      Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 0.125, 0.25, OR 0.5 M: 0, .25, .5, OR 1.0 MG/M3; 50/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Inhalation; Intravenous)  (K60344)  Completed 
    • Citation: Toxicokinetics of 63Ni After Inhalation of Three Concentrations of Nickel Sulfate Hexahydrate (1989)
    • Male Rats: Fischer 344
    • Dose: 0.735, 1.96, and 11.7 ug/L. 4 ug.

Genetic Toxicology

  • Mouse Lymphoma  (411811)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (A45391)  Completed 
    •  Negative