Testing Status of 4-Chloro-2-nitroaniline 10208-C

 

CASRN: 89-63-4

Formula: C6-H5-Cl-N2-O2

Synonyms/Common Names

  • 4-Chloro-2-nitrobenzenamine

Known Uses

Dye and pigment intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C60355A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C60355A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 50, 800, M: 0, 75, 1200 MG/KG/10 PER GROUP.

Special Studies

  • Metabolism (Intravenous)  (S0027)  Completed 
    • Citation: Chopade HM, Matthews HB. Disposition and metabolism of 4-chloro-2-nitroaniline in the male F344 rat. J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):267-82.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 1 MICROMOL=0.172 MG-0.788, 7.88, 78.8 MICROM/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (908592)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (971790)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (790805)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive