National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10209-f

Testing Status of C.I. Pigment Red 3 - 10209-F

 

CASRN: 2425-85-6

Formula: C17-H13-N3-O3

Synonyms/Common Names

  • 1-((4-Methyl-2-nitrophenyl)azo)-2-naphthalenol
  • Red 3, C.I. Pigment

Known Uses

Used in manufacture of paints, inks, plastics, and rubber.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C60366)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C60366)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C60366)  Report Complete 
    • TR-407 (NIH Number: 92-3138)  (Peer Review Approval 07/09/1991A )
      Toxicology and Carcinogenesis Studies of C.I. Pigment Red 3 (CASRN 2425-85-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 6000, 12500, 25000; M: 0, 12500, 25000, 50000 PPM (60 PER GROUP).

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0030)  Completed 
    • Citation: El Dareer SM, Tillery KF, Hill DL. Investigations on the disposition of oral doses of some water-insoluble pigments. Bull Environ Contam Toxicol. 1984 Feb;32(2):171-4.Pubmed Abstract
    • Rats

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (069775)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (945354)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
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