National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10217-f

Testing Status of p-Nitroaniline - 10217-F

 

CASRN: 100-01-6

Formula: C6-H6-N2-O2

Synonyms/Common Names

  • 4-Nitrobenzeneamine (9CI)

Known Uses

Intermediate for antioxidants, dyes, pigments, gasoline gum inhibitors, veterinary medicine for poultry, pharmaceuticals (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C60786A)  Completed 
    • Mice: B6C3F1
  • 13 weeks (Gavage)  (C60786A)  Completed 
    • Mice: B6C3F1
    • Dose: 0,1,100 MG/10ML/KG/40 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60786B)  Report Complete 
    • TR-418 (NIH Number: 93-3149)  (Peer Review Approval 11/21/1991A )
      Toxicology and Carcinogenesis Studies of p-Nitroaniline (CASRN 100-01-6) in B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: 0,3,30,100 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0025)  Completed 
    • Citation: Chopade HM, Matthews HB. Disposition and metabolism of p-nitroaniline in the male F-344 rat. Fundam Appl Toxicol. 1984 Jun;4(3 Pt 1):485-93.Pubmed Abstract
    • Rats
    • Dose: PO: 2, 100; IV:10 MICROMOL/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (491256)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (786885)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (344224)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (396966)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (368298)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (074958)  Completed 
    •  Positive 
  • Salmonella  (615042)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0046)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 1200 MG/KG BD WT.
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