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Testing Status of Riddelliine 10237-W

 

CASRN: 23246-96-0

Formula: C18-H23-N-O6

Synonyms/Common Names

  • Riddelline
  • Senecionan-11,16-dione, 13,19-didehydro-12,18-dihydroxy- (9CI)

Known Uses

Naturally occurring pharmaceutical agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C61358B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0, 0.33, 1.0, 3.3, 10.0, 25.0 MG/KG (5/S/S).
  • 13 weeks (Gavage)  (C61358B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R:0, 0.1, 0.33, 1.0, 3.3, 10.0 MG/KG; M:0, 0.33, 1.0, 3.3, 10.0, 25.0 MG/KG (10/S/S).

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C61358C)  Completed 
    • TR-508 (NIH Number: 03-4442)  (Peer Review Approval 10/18/2001A )
      Toxicology and Carcinogenesis Studies of Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: MR: 0 OR 1.0 MG/KG; 50/DOSE FR: 0, 0.01, 0.033, 0.1, 0.33, OR 1.0 MG/KG; 62/DOSE MM: 0, 0.1, 0.3, 1.0, OR 3.0 MG/KG; 50/DOSE FM: 0 OR 3.0 MG/KG; 50/DOSE.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (762742)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A52780)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (532340)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive