National Toxicology Program

National Toxicology Program

Testing Status of beta-Bromo-beta-nitrostyrene - 10245-W


CASRN: 7166-19-0

Formula: C8-H6-Br-N-O2

Synonyms/Common Names

  • Benzene, (2-bromo-2-nitroethenyl)-

Known Uses

Use in water cooling towers, food-contracting paper, added to water used in pulp & paper manufacture, in cationic detergents as slime control, pesticide (ACS 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Gavage)  (C60855)  Report Complete 
    • TOX-40 (NIH Number: 94-3389)  (Tox Peer Review 01/00/1994A )
      Toxicity Studies of b-Bromo-b-Nitrostyrene (CASRN 7166-19-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M 0, 0.037, 0.075, 0.3, 0.15, 0.6 G/KG; 10/GRP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0088)  Completed 
    • Male Rats: F344/N; Rats: F344/N
    • Dose: PO:1,1.2,10,12,98,120; IV:9.1-9.7 MG/KG.

Genetic Toxicology

  • Micronucleus  (A05982)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Negative 
  • Micronucleus  (A40359)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A43432)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (535038)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.