National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10248-h

Testing Status of Carisoprodol - 10248-H

 

CASRN: 78-44-4

Formula: C12-H24-N2-O4

Synonyms/Common Names

  • Carbamic acid, (1-methylethyl)-, 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester

Known Uses

Skeletal muscle relaxant

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C56235A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Gavage)  (C56235A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 25, OR 400 MG/KG/10 PER GROUP.
  • 13 weeks (Gavage)  (C56235B)  Completed 
    • TOX-56 (NIH Number: 00-4404)
      Toxicity Studies of Carisoprodol (CASRN 78-44-4) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,25,400 MG/KG/5 PER GROUP.
  • 13 weeks (Gavage)  (C56235C)  Report Complete 
    • TOX-56 (NIH Number: 00-4404)  (Tox Peer Review 01/29/1999A )
      Toxicity Studies of Carisoprodol (CASRN 78-44-4) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 100, 200, 400, OR 800 MG/KG; 10/SEX/GROUP M: 0, 600, 1200, OR 1600 MG/KG; 10/SEX/GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (789521)  Completed 
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (071860)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (A09820)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (238333)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Gavage)  (RACB88037)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Carisoprodol in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0,100,300,600,900,1200 MG/KG/DAY; 0,300,750,1200 MG/KG/DAY; 0,1200 MG/KG/DAY; 0,300,750,1200 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.