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Testing Status of Crotonaldehyde 10252-S

 

CASRN: 4170-30-3

Formula: C4-H6-O

Synonyms/Common Names

  • 2-Butenal

Known Uses

Intermediate for solvents, accelerators & insecticides. Purification of mineral oils. Warning agent in fuel gases, in rubber antioxidants, chemical warfare agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56279B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56279B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: M: 0, 2.5, 40 MG/KG/10 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0069)  Completed 
    • Male Rats
    • Dose: IV: 3 MG/KG PO: 0.7, 3, 35 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (497791)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (854224)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Micronucleus  (A99101)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (097471)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM88035)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.3, 1.0, 3.0 % FOR SENSITIZATION; 10% FOR CHALLENGE; DNFB (0.5%) AS POSITIVECONTROL..
  • males: 1 day until necropsy (71 to 72 days) females: 31 days until necropsy (pospartum 5 days: pregnant and 99 day: non-pregnant) Continuous Breeding (Legacy) (Gavage)  (RACB87001)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 0, 2.5, 5, OR 10 MG/KG.